{"id":87506,"date":"2023-08-07T15:12:17","date_gmt":"2023-08-07T07:12:17","guid":{"rendered":"http:\/\/www.broadbio.com\/?p=87506"},"modified":"2023-08-07T15:12:19","modified_gmt":"2023-08-07T07:12:19","slug":"nrc%e6%a0%87%e5%87%86%e5%93%81%e8%99%be%e5%a4%b7%e6%89%87%e8%b4%9d%e6%af%92%e7%b4%a0%e8%ae%a4%e8%af%81%e6%a0%a1%e5%87%86%e6%ba%b6%e6%b6%b2crm-ytx-c%e5%88%b6%e5%a4%87","status":"publish","type":"post","link":"http:\/\/www.broadbio.com\/archives\/87506","title":{"rendered":"NRC\u6807\u51c6\u54c1\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2CRM-YTX-c\u5236\u5907"},"content":{"rendered":"\n

\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2<\/p>\n\n\n\n

\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\uff08YTXs\uff09\u662f\u4e00\u7ec4\u7531\u5404\u79cd\u7532\u85fb\u4ea7\u751f\u7684\u591a\u73af\u919a\u7c7b\u5316\u5408\u7269\uff0c\u5305\u62ec\u7f51\u72b6\u539f\u89d2\u85fb\u3001\u591a\u9f13\u7075\u85fb\u548c\u523a\u521a\u85fb[1]\u3002\u4eba\u7c7b\u98df\u7528\u7684\u8d1d\u7c7b\u4e2d\u67d0\u4e9bYTX\u7684\u6700\u9ad8\u5141\u8bb8\u6c34\u5e73\u662f\u6709\u89c4\u5b9a\u7684[2]\u3002CRM-YTX-c\u662fYTX\u5728\u7532\u9187\u4e2d\u7684\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2\uff0c\u662f2012\u5e74\u53d1\u5e03\u7684CRM-YTX-b\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n\n\n\n

Yessotoxin (protonated form)        \u867e\u5937\u6247\u8d1d\u6bd2\u7d20\uff08\u8d28\u5b50\u5316\u5f62\u5f0f\uff09<\/p>\n\n\n\n

CAS registry No.: 112514-54-2       CAS\u6ce8\u518c\u53f7\uff1a1125145-4-2<\/p>\n\n\n\n

Molecular formula: C55H82O21S2         \u5206\u5b50\u5f0f\uff1aC55H82O21S2<\/p>\n\n\n\n

Molecular weight: 1143.4 g\/mol    \u5206\u5b50\u91cf\uff1a1143.4\ng\/mol<\/p>\n\n\n\n

[M-H]- : m\/z 1141.4717  [M-H]-\uff1aM\/z\n1141.4717<\/p>\n\n\n\n

[M-2H]2- : m\/z 570.2322         [M-2H]2-\uff1aM\/z 570.2322<\/p>\n\n\n\n

Yessotoxin (sodium salt form)         \u867e\u5937\u6247\u8d1d\u6bd2\u7d20\uff08\u94a0\u76d0\u5f62\u5f0f\uff09<\/p>\n\n\n\n

Molecular formula: C55H80O21S2Na2 \u5206\u5b50\u5f0f\uff1aC55H80O21S2Na2<\/p>\n\n\n\n

Molecular weight: 1187.3 g\/mol     \u5206\u5b50\u91cf\uff1a1187.3\ng\/mol<\/p>\n\n\n\n

\u9884\u671f\u7528\u9014<\/p>\n\n\n\n

NRC\u6807\u51c6\u54c1\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2CRM-YTX-c<\/strong>\u662f\u4e00\u79cd\u7ecf\u8fc7\u8ba4\u8bc1\u7684\u6821\u51c6\u6eb6\u6db2\uff0c\u4e13\u4e3aYTX\u7684\u5206\u6790\u65b9\u6cd5\u5f00\u53d1\u548c\u51c6\u786e\u5b9a\u91cf\u800c\u8bbe\u8ba1\u3002CRM-YTX-c\u7684\u6d53\u5ea6\u4f7f\u5176\u9002\u7528\u4e8e\u5236\u5907\u7528\u4e8e\u6821\u51c6\u6db2\u76f8\u8272\u8c31\uff08LC\uff09\u548c\u6db2\u76f8\u8272\u8c31-\u8d28\u8c31\uff08LC-MS\uff09\u4eea\u5668\u7684\u7a00\u91ca\u7cfb\u5217\uff0c\u4ee5\u53ca\u7528\u4e8e\u56de\u6536\u5b9e\u9a8c\u7684\u8d1d\u7c7b\u5bf9\u7167\u6837\u54c1\u7684\u52a0\u6807\u3002<\/p>\n\n\n\n

\u50a8\u5b58\u548c\u4f7f\u7528\u8bf4\u660e<\/p>\n\n\n\n

\u4e3a\u786e\u4fddNRC\u6807\u51c6\u54c1\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2CRM-YTX-c<\/strong>\u7684\u7a33\u5b9a\u6027\uff0c\u5b89\u74ff\u5e94\u50a8\u5b58\u5728-12\u00b0c\u6216\u4ee5\u4e0b\u3002\u6253\u5f00\u524d\uff0c\u5e94\u5c06\u6bcf\u4e2a\u5b89\u74ff\u52a0\u70ed\u81f3\u5ba4\u6e29\uff0c\u5e76\u5c06\u5185\u5bb9\u7269\u5145\u5206\u6df7\u5408\u3002\u5b89\u74ff\u5e94\u5728\u9884\u5148\u523b\u597d\u7684\u6807\u8bb0\u5904\u6253\u5f00\u3002\u5b89\u74ff\u6253\u5f00\u540e\uff0c\u5e94\u4f7f\u7528\u6821\u51c6\u7684\u5bb9\u91cf\u8bbe\u5907\u53d6\u51fa\u51c6\u786e\u7684\u7b49\u5206\u8bd5\u6837\uff0c\u5e76\u5c06\u5176\u8f6c\u79fb\u5230\u5bb9\u91cf\u74f6\u6216\u5c0f\u74f6\u4e2d\u3002\u5982\u679c\u6eb6\u6db2\u6253\u5f00\u8d85\u8fc7\u51e0\u5206\u949f\uff0c\u5219\u4f1a\u56e0\u7532\u9187\u84b8\u53d1\u800c\u5bfc\u81f4\u6d53\u5ea6\u589e\u52a0\u3002\u5efa\u8baeCRM-YTX-c\u7684\u6eb6\u6db2\u4e0d\u5e94\u84b8\u53d1\u81f3\u5e72\uff0c\u56e0\u4e3a\u73bb\u7483\u8868\u9762\u53ef\u80fd\u4f1a\u6709\u635f\u5931\u3002\u6ce8\uff1a\u6eb6\u6db2\u7684\u4f53\u79ef\u672a\u7ecf\u8ba4\u8bc1\uff1b\u53ea\u6709\u6d53\u5ea6\u88ab\u8bc1\u660e\u3002\u56e0\u6b64\uff0c\u5b89\u74ff\u7684\u5168\u90e8\u5185\u5bb9\u7269\u4e0d\u5e94\u7b80\u5355\u5730\u8f6c\u79fb\u5230\u5bb9\u91cf\u74f6\u4e2d\u5e76\u7a00\u91ca\u81f3\u4e00\u5b9a\u4f53\u79ef\u3002<\/p>\n\n\n\n

NRC\u6807\u51c6\u54c1\u867e\u5937\u6247\u8d1d\u6bd2\u7d20\u8ba4\u8bc1\u6821\u51c6\u6eb6\u6db2CRM-YTX-c<\/strong>\u7684\u5236\u5907<\/p>\n\n\n\n

YTX\u662f\u4ece\u65b0\u897f\u5170Cawthron\u7814\u7a76\u6240\u57f9\u517b\u7684\u7532\u85fb\uff08Protoceratium reticulatum\uff09\u4e2d\u5206\u79bb\u51fa\u6765\u7684\u3002YTX\u7684\u5236\u5907\u63d0\u53d6\u548c\u7eaf\u5316\u5728Cawthron\u7814\u7a76\u6240\u8fdb\u884c[3]\u3002\u6700\u7ec8\u7eaf\u5ea6\u6b65\u9aa4\u548c\u8bc4\u4f30\u5728\u54c8\u5229\u6cd5\u514b\u65afNRC\u5b8c\u6210\u3002\u901a\u8fc71H NMR\u548c\u9ad8\u5206\u8fa8LC-MS\u5bf9YTX\u7684\u7ed3\u6784\u548c\u7eaf\u5ea6\u8fdb\u884c\u4e86\u786e\u8bc1\u3002YTX\u7684[m-H]-\u79bb\u5b50\u7684\u6d4b\u91cf\u51c6\u786em\/z\u4e3a1141.4704\u00b10.0001\uff08\u5bf9\u4e8eC55H81O S-\uff0c\u2206=-1.1 ppm\uff09\uff08\u56fe1A\uff09\u3002\u78b0\u649e\u8bf1\u5bfc\u7684\u79bb\u89e3\u5149\u8c31\uff08\u56fe1B\uff09\u4e0e\u4e4b\u524d\u7684YTX CRM\u548c\u6587\u732e\u62a5\u9053[4]\u76f8\u5339\u914d\u3002<\/p>\n\n\n\n

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