{"id":328,"date":"2019-11-04T10:07:31","date_gmt":"2019-11-04T02:07:31","guid":{"rendered":"http:\/\/www.broadbio.com\/?p=328"},"modified":"2019-11-04T10:07:31","modified_gmt":"2019-11-04T02:07:31","slug":"1141","status":"publish","type":"post","link":"http:\/\/www.broadbio.com\/archives\/328","title":{"rendered":"\u73b0\u8d27\u4f9b\u5e94\u5b89\u7acb\u751f\u5766\u6742\u8d28\u5bf9\u7167\u54c1Ambrisentan\u00a0Impurity\uff08\u63d0\u4f9bCOA\u53ca\u7eaf\u5ea6\u7ed3\u6784\u786e\u8ba4\u56fe\u8c31\uff09"},"content":{"rendered":"

\u73b0\u8d27\u4f9b\u5e94\u5b89\u7acb\u751f\u5766\u6742\u8d28\u5bf9\u7167\u54c1<\/strong>Ambrisentan\u00a0Impurity\uff08<\/strong>\u63d0\u4f9bCOA<\/strong>\u53ca\u7eaf\u5ea6\u7ed3\u6784\u786e\u8ba4\u56fe\u8c31\uff09<\/strong><\/p>\n

\"\"<\/p>\n

\u5b89\u7acb\u751f\u5766\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan\u00a0\u00a0 CAS No.\u00a0177036-94-1\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u7f9f\u916f\u6742\u8d28\/\u5b89\u7acb\u751f\u5766\u6742\u8d28\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan Hydroxyester Impurity\u00a0\u00a0\u00a0\u00a0 CAS No.\u00a0177036-78-1\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u6c2e\u6c27\u5316\u7269\/\u5b89\u7acb\u751f\u5766\u6742\u8d28\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan\u00a0N-Oxide\u00a0\u00a0\u00a0 C22H22N2O5\u00a0M.W.\u00a0394.43\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766-\u7ef4\u5c3c\u6c27\u57fa\u6742\u8d28\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan Vinyloxy Impurity\u00a0\u00a0\u00a0 CAS No.\u00a01639429-81-4 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

4-\u7f9f\u57fa\u7532\u57fa\u5b89\u7acb\u751f\u5766-D3\u00a0\u00a0\u00a0\u00a0\u00a0 4-Hydroxy Methyl Ambrisentan-D3\u00a0\u00a0\u00a0\u00a0 C22H19N2O5D3\u00a0M.W.\u00a0397.45\u00a0\u00a0\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u5627\u5576\u916f\u6742\u8d28\u00a0\u00a0\u00a0 Ambrisentan pyrimidine Ester Impurity\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C23H24N2O4\u00a0M.W.\u00a0392.46\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

rac-\u5b89\u7acb\u751f\u5766-d5\u578b\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 rac-Ambrisentan-d5\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CAS No.\u00a01392210-85-3 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\uff08R\uff09-\u5b89\u7acb\u751f\u5766\/\u5b89\u7acb\u751f\u5766\u6742\u8d28\u00a0\u00a0 (R)-Ambrisentan\u00a0\u00a0\u00a0 CAS No.\u00a01007358-76-0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u7f9f\u57fa\u9178\u6742\u8d28\/\u5b89\u7acb\u751f\u5766\u6742\u8d28\u00a0\u00a0 Ambrisentan Hydroxy Acid Impurity\u00a0\u00a0\u00a0 CAS No.\u00a0178306-52-0\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u7f9f\u57fa\u9178\u6742\u8d28\uff08R-\u5f02\u6784\u4f53\uff09\u00a0\u00a0\u00a0 Ambrisentan Hydroxy Acid Impurity (R-isomer) C16H16O4\u00a0M.W.\u00a0272.30\u00a0\u00a0\u00a0\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

4-\u7f9f\u7532\u57fa\u6c28\u82ef\u4e09\u6c2e\u9170\u57fa\u03b2-\u8461\u8404\u7cd6\u919b\u9178\u00a0\u00a0\u00a0\u00a0\u00a0 4-Hydroxymethyl ambrisentan acyl\u00a0beta-glucuronide\u00a0 C28H30N2O11\u00a0M.W.\u00a0570.55 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u9170\u57fa\u8461\u8404\u7cd6\u919b\u9178\uff08\u975e\u5bf9\u6620\u4f53\u6df7\u5408\u7269\uff09\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan Acyl Glucuronide (Mixture of Diastereomers)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C28H30N2O10\u00a0M.W.\u00a0554.56\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

4-\u7f9f\u57fa\u7532\u57fa\u5b89\u7720\u4e39 4-Hydroxy Methyl Ambrisentan\u00a0\u00a0\u00a0 CAS No.\u00a01106685-66-8 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766\u6742\u8d281\u00a0\u00a0\u00a0\u00a0 Ambrisentan Impurity 1 CAS No.\u00a01312092-82-2 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

3\uff0c3-\u4e8c\u82ef\u57fa\u6c27\u7fb0\u57fa\u7532\u9178\u7532\u916f\u00a0\u00a0\u00a0\u00a0\u00a0 3,3-Diphenyl-oxiranecarboxylic Acid Methyl Ester\u00a0\u00a0\u00a0\u00a0 76527-25-8\u00a0\u00a0\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7720\u4e39\u9170\u03b2-d-\u8461\u8404\u7cd6\u919b\u9178\u00a0\u00a0 Ambrisentan Acyl \u03b2-D-Glucuronide\u00a0\u00a0 1106685-58-8 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

rac\u5b89\u7acb\u751f\u5766\u6c2f\u5316\u94f5\u7532\u916f\u00a0\u00a0\u00a0\u00a0\u00a0 rac Ambrisentan Methyl Ester\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1240470-84-1 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

2-\u7f9f\u57fa-3-\u7532\u6c27\u57fa-3,3-\u4e8c\u82ef\u4e19\u9178-d3\u7532\u916f\u00a0\u00a0\u00a0\u00a0 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid-d3 Methyl Ester 1046116-52-2 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

2-\u7f9f\u57fa-3-\u7532\u6c27\u57fa-3,3-\u4e8c\u82ef\u4e19\u9178\u7532\u916f\u00a0\u00a0 2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid Methyl Ester\u00a0\u00a0\u00a0\u00a0\u00a0 178306-47-3\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

4,6-\u4e8c\u7532\u6c27\u57fa-\u03b2-\u7532\u57fa-3-\u82ef\u6c27\u57fa\u7425\u73c0\u9178\u916f\u00a0 4,6-Dimethoxy-\u03b2-methyl-3-phenoxy Ambrisentan\u00a0\u00a0\u00a0\u00a0 159308-03-9\u00a0\u00a0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

rac-ambrisentan-d3\u7532\u916f\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 rac Ambrisentan-d3 Methyl Ester\u00a0 1329837-75-3 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\u5b89\u7acb\u751f\u5766-D10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ambrisentan-d10\u00a0\u00a0\u00a0 1046116-27-1 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

\uff08S\uff09-4-\u7f9f\u7532\u57fa\u7425\u73c0\u9178\u916f\u00a0\u00a0\u00a0 (S)-4-Hydroxymethyl Ambrisentan\u00a0\u00a0\u00a0\u00a0\u00a0 1106685-66-8 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

2-\uff08\uff082,2-\u4e8c\u82ef\u57fa\u4e59\u70ef\u57fa\uff09\u6c27\u57fa\uff09-4,6-\u4e8c\u7532\u57fa\u5627\u5576\u00a0\u00a0\u00a0 2-((2,2-Diphenylvinyl)oxy)-4,6-dimethylpyrimidine\u00a0\u00a0 1639429-81-4 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

AMBRISENTAN-D3\u8dd1\u9053\u00a0\u00a0\u00a0 rac Ambrisentan-d3\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1189479-60-4 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

rac 4-\u7f9f\u7532\u57fa\u7425\u73c0\u9178\u916f\u00a0 rac 4-Hydroxymethyl Ambrisentan\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1106685-84-0 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

rac 4-\u7f9f\u7532\u57fa\u7425\u73c0\u9178\u916f-d3\u00a0\u00a0\u00a0\u00a0 rac 4-Hydroxymethyl Ambrisentan-d3\u00a0 1287096-42-7 \u6df1\u5733\u5fb7\u535a\u745e<\/p>\n

4,6-\u4e8c\u7532\u6c27\u57fa-\u03b2-\u7532\u57fa-3-\u82ef\u6c27\u57fa\u7425\u73c0\u70f7-D5\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 4,6-Dimethoxy-\u03b2-methyl-3-phenoxy Ambrisentan-d5\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1346597-40-7<\/p>\n

\u6df1\u5733\u5fb7\u535a\u745e\u66f4\u591a\u4ea7\u54c1\u8be6\u7ec6\u4fe1\u606f\uff0c\u6b22\u8fce\u6765\u7535\u8be6\u8be2\uff0c\u4ec5\u4f9b\u5b9e\u9a8c\u5ba4\u4f7f\u7528\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u73b0\u8d27\u4f9b\u5e94\u5b89\u7acb\u751f\u5766\u6742\u8d28\u5bf9\u7167\u54c1Ambrisentan\u00a0Impurity\uff08\u63d0\u4f9bCOA\u53ca\u7eaf\u5ea6\u7ed3\u6784\u786e\u8ba4\u56fe\u8c31\uff09 \u5b89\u7acb\u751f\u5766\u00a0 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/posts\/328"}],"collection":[{"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/comments?post=328"}],"version-history":[{"count":1,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/posts\/328\/revisions"}],"predecessor-version":[{"id":329,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/posts\/328\/revisions\/329"}],"wp:attachment":[{"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/media?parent=328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/categories?post=328"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.broadbio.com\/wp-json\/wp\/v2\/tags?post=328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}